John F. Engelhardt
Director, University of Iowa Center for Gene Therapy of Cystic Fibrosis
John F. Engelhardt, PhD
directs the Center for Gene Therapy of Cystic Fibrosis and is a Professor and Head of the Department of Anatomy and Cell Biology at the University of Iowa Carver College of Medicine.
Dr. Engelhardt's research focuses on the development of gene therapies for inherited and environmentally induced diseases. Included are three major areas of research emphasis:
1) the study of lung molecularand cellular biology as it relates to the pathogenesis and treatment of cystic fibrosis (CF) lung disease and associated diabetes,
2) molecular mechanisms underlying redox-mediated signal transduction in environmental injuries of the liver and the development of molecular therapies for ischemia/reperfusion injury, sepsis, and the neurodegenerative disease amyotrophic lateral sclerosis (ALS), and
3) the biology of adeno-associated virus infection and the development of this vector for gene therapy of cystic fibrosis lung disease.
Research on lung biology includes the study of adult epithelial stem cells and their niches in the airway, and dissecting the pathogenesis of lung disease in animal models
of cystic fibrosis. The laboratory is currently elucidating transcriptional signals important for early establishment of the airway glandular stem cell niche, and for
mobilization of stem cells from this niche following airway injury.